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Zeolite-encapsulated Mn(II) Complex: A New Nano Catalyst for the Synthesis of Modafinil and Its Derivatives

Author(s):

Mohammad Javad Taghizadeh*, Homman Karimi and Akbar Mirzaie   Pages 1 - 9 ( 9 )

Abstract:


The Mn-hydrazone Schiff base encapsulated into NaY has been prepared and characterized as a new heterogeneous catalyst. Elemental analysis, UV-Vis, infrared spectroscopic analysis, diffused reflectance spectroscopy, thermal analysis, small angle X-ray diffraction, and N2 sorption demonstrate the existence of Mn-hydrazone schiff base in the nanopores of zeolite-Y. MnII(Hsal- hrz)/Y, which showed excellent catalytic property in oxidation with various sulfide compounds including important drugs such as adrafinil and modafinil, using hydroperoxide-urea (UHP) as oxidant. Thioanisole conversion was high (98%).

Keywords:

Heterogeneous catalyst, sulfoxidation, adrafinil, modafinil.

Affiliation:

Faculty of Science, University of Imam Hossein, Department of Chemistry, Faculty of Science, University of Sharif Department of Chemistry, Faculty of Science, University of Imam Hossein, Department of Chemistry



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