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Microwave-Assisted Synthesis of Novel Bis-Flavone Dimers as New Anticancer Agents

[ Vol. 16 , Issue. 1 ]

Author(s):

Andrew McGown, Abby Ragazzon-Smith, John A. Hadfield, Herman Potgetier and Patricia A. Ragazzon*   Pages 66 - 75 ( 10 )

Abstract:


In this study, we describe a microwave-based click chemistry method used to prepare a family of novel bis-flavone dimers. The substituted 7-hydroxy and 4’-hydroxy flavonoids were linked through a triazole ring. The compounds were easily synthesized and purified in high yields. The bisflavonoids were tested on different cell lines including HCT116, HepG2, MCF7 and MOLT-4. Several analogues showed to have anticancer activity with IC50 values in the range of 20-60 μM. Flavonoids are known for their anticancer properties and this method provides the basis for new medicinal structures.

Keywords:

Flavonoid, bis-flavonoid, green-chemistry, click-chemistry, microwave-assisted chemistry, anticancer.

Affiliation:

Biomedical Research Centre, Environment and Life Sciences, University of Salford, Salford, Biomedical Research Centre, Environment and Life Sciences, University of Salford, Salford, Biomedical Research Centre, Environment and Life Sciences, University of Salford, Salford, School of Science and the Environment, Manchester Metropolitan University, Manchester, School of Pharmacy, Keele University, Staffordshire

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