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Diethylphosphoryl-OxymaB (DEPO-B) as a Solid Coupling Reagent for Amide Bond Formation

[ Vol. 16 , Issue. 1 ]

Author(s):

Ashish Kumar, Yahya E. Jad, Ayman El-Faham, Beatriz G. de la Torre* and Fernando Albericio*   Pages 30 - 33 ( 4 )

Abstract:


A new phosphonium based coupling reagent DEPO-B has been synthesized from 5- (hydroxyimino)-1,3-dimethylpyrimidine-2,4,6 (1H,3H,5H)-trione (Oxyma B) and diethyl chlorophosphate in presence of base. It is a solid material and the hydrolytic stability and solubility was evaluated for confirming its capability for usage in automated peptide synthesizer.

Keywords:

Coupling reagent, phosphonium salts, diethylphosphoryl-OxymaB, hydrolytic stability, solubility.

Affiliation:

School of Health Sciences, University of KwaZulu-Natal, Durban 4001, School of Health Sciences, University of KwaZulu-Natal, Durban 4001, Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, School of Health Sciences, University of KwaZulu-Natal, Durban 4001, Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451

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