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Efficient CDI/CH3SO3H -Catalyzed, Microwave-Assisted Synthesis of 2-Substituted Benzothiazoles

[ Vol. 16 , Issue. 1 ]

Author(s):

Yao-Wei Li, Pei-Ming Zhang, Rui Li, Yan Bai, Yu Yu* and Zong-Jie Gan*   Pages 34 - 39 ( 6 )

Abstract:


CDI combined with CH3SO3H was found to be highly effective for the cyclization of 2-aminothiophenol derivatives with carboxylic acids under MW condition. Fourteen benzothiazole derivatives were synthesized in good yield and their structures were characterized by 1H-NMR, 13CNMR, IR and mass spectrometry. This simple, rapid synthetic method is believed to provide a useful process for the synthesis of 2-substituted benzothiazole compounds.

Keywords:

2-substituted benzothiazoles, CDI/CH3SO3H, 2-aminothiophenol, microwave irradiation, room temperature, mass spectrometry.

Affiliation:

Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016

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