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A Facile Procedure for Synthesis of Several 1, 4, 5-Trisubstituted-1Himidazole- 2(3H)-ones and -thiones via a One-pot Three-portion Reaction in Solvent and Microwave Irradiation

[ Vol. 16 , Issue. 2 ]


Mohammad Shaker*   Pages 104 - 109 ( 6 )


An ordinary procedure for the synthesis of several 1, 4, 5-trisubstituted-1H-imidazole- 2(3H)-ones and -thiones by a one-pot three-component reaction of glacial acetic acid under solvent, microwave irradiation condition is proposed. The products were formed through cyclization of benzoin with isothiocyanates or isocyanates and ammonium acetate. All incorporated combinations were determined for their spectral and microanalytical information. These compounds were subsequently studied for their fluorescence properties.


Trisubstituted- 1H- imidazole- 2(3H)- ones and -thiones, multicomponent reactions, microwave irradiation, fluorescence, emission and absorption spectra, acetic acid.


Department of Chemistry, Mashhad Branch, Islamic Azad University, Mashhad

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