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An Efficient and Straightforward Total Synthesis of (±)-Preclamol

[ Vol. 15 , Issue. 12 ]

Author(s):

Ravi Lakkakula, K. Mukkanti and Arnab Roy*   Pages 1065 - 1069 ( 5 )

Abstract:


A prudent and scalable synthesis of (±)-Preclamol is described utilizing Michael addition and in-situ reduction/cyclization of an aryl-α-carbethoxy acetonitrile derivative as a key step.

Keywords:

Michael addition, in-situ reduction/cyclization, preclamol, risperidone, alogliptin, ritalin.

Affiliation:

GVK Biosciences Private Limited, Plot No. 28 A, IDA Nacharam, Hyderabad - 500076, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad-500085, GVK Biosciences Private Limited, Plot No. 28 A, IDA Nacharam, Hyderabad - 500076

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