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Cytotoxic Pyran-based Cembranoids from Sarcophyton glaucum

[ Vol. 15 , Issue. 11 ]

Author(s):

Walied M. Alarif*, Zahra A. Al-Saihati, Mohamed H. Ph, Ahmed Abdel-Lateff, Mahmoud A. Elfaky, Nahed O. Bawakid, Najla A. Alburae and Hajer S. Alorfi   Pages 967 - 971 ( 5 )

Abstract:


Four new pyran-based cembranoidal diterpenes (1-4) were isolated from the Red Sea softbodied coral Sarcophyton glaucum. Sarcoglauphine A (1) and B (2) are conformers with respect to the dihedral angle between H-7 and the pair of H-6a, 6b, while sarcotrocheliol-B acetate (3) and sarcotrochelione (4) are bicyclic cembranoids. The chemical structures of the isolated compounds were elucidated using spectroscopic methods. The cytotoxicity of the isolated compounds were evaluated against HepG2, MCF-7, and HCT116 cell lines by employing Sulforhodamine B (SRB) method. Compounds 1 and 2 showed significant activities toward HCT116.

Keywords:

Soft coral, red sea, isomers, oxirane, diterpenoids, cemberane.

Affiliation:

Department of Marine Chemistry, Faculty of Marine Sciences, King Abdulaziz University, P.O. Box 80207, Jeddah 21589, Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Department of Biology, Faculty of Science, King Abdulaziz University, P.O. Box 80207, Jeddah 21589, Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589

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