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A Facile, Efficient and Convenient Synthesis of 1,8-Dioxodecahydroacridines with PMA-SiO2 Reusable Catalyst

[ Vol. 15 , Issue. 11 ]

Author(s):

Madala Subramanyam, Ravi Varala, Reddymasu Sreenivasulu*, Mandava Venkata Basaveswara Rao and Koya Prabhakara Rao*   Pages 915 - 921 ( 7 )

Abstract:


Multi component reactions (MCRs) are emerged as the most an effective and efficient tool in modern synthetic organic chemistry in the recent years. Syntheses of complex and diverse organic molecules from simple and readily available starting materials in a single step can be achieved by MCRs. We achieved PMA-SiO2 catalysed synthesis of 1,8-dioxodecahydroacridines through multi component reactions (MCRs) of 5, 5-dimethylcyclohexane-1, 3-dione, aldehydes and anilines in PEG- 400. Moreover, varieties of dioxodecahydroacridine derivatives were also synthesized in good yields by using PMA-SiO2 catalyst. The reaction proceeded efficiently in all these cases affording a diversity of 5-substituted 1, 8-dioxodecahydroacridine derivatives 6(a-i), in reasonably good yields. A range of electron donating and electron with drawing groups present on the aromatic ring of aldehydes was well tolerated for the titled catalyst, PMA-SiO2 and obtained good yields. PMA-SiO2 in PEG-400 catalyst offers several advantages like shorter reaction times, non-toxic, mild reaction conditions, cleaner reactions, high yield of the products, lower catalytic loading etc. Moreover, this catalyst could be recovered and recycled easily for several cycles without losing its activity. This study can provide a road map to design new green synthetic methodologies for single step cyclo-condensation reaction through MCRs with better yields.

Keywords:

Acridines, multi component reactions, PEG-400, PMA-SiO2, catalyst, DHP.

Affiliation:

New Generation Materials Lab (NGML), Department of Science and Humanities, Vignan`s Foundation for Science, Technology and Research (VFSTR) University, Vadlamudi, Guntur - 522 213, Andhra Pradesh, Department of Chemistry, Rajiv Gandhi University for Knowledge and Technology (RGUKT), Basar - 504107, Telangana State, Department of Chemistry, University College of Engineering (Autonomous), Jawaharlal Nehru Technological University, Kakinada - 533003, Andhra Pradesh, Department of Chemistry, Dr. MRAR. PG Centre, Krishna University, Nuzvid - 521 201, Andhra Pradesh, New Generation Materials Lab (NGML), Department of Science and Humanities, Vignan`s Foundation for Science, Technology and Research (VFSTR) University, Vadlamudi, Guntur - 522 213, Andhra Pradesh

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