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Direct and Facile Synthesis of Primary Amides from Carboxylic Acids via Acyl Isocyanate Intermediates Using Mukaiyama Reagent

[ Vol. 15 , Issue. 9 ]

Author(s):

Roya Azadi* and Zahra Motamedpoor   Pages 801 - 804 ( 4 )

Abstract:


A very simple and efficient procedure for the preparation of primary amides is described from carboxylic acids using Mukaiyama reagent/KNCO in aqueous acetonitrile. Availability of the reagents, simplicity, and easy workup of the reaction crude make this method attractive for organic chemists.

Keywords:

2-Chloro-1-methylpyridinium iodide, acyl isocyanate, amide, carboxylic acid, mukaiyama reagent.

Affiliation:

Chemistry Department, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Chemistry Department, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz

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