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Practical and Efficient Synthesis of Hydroxyaryl Ketones Catalyzed by HF@SiO2 under Solvent-free Condition

[ Vol. 15 , Issue. 9 ]

Author(s):

Hossein Paghandeh, Hamid Saeidian* and Mohammad Ghaffarzadeh   Pages 809 - 814 ( 6 )

Abstract:


A wide variety of hydroxyaryl ketones bearing different motifs was successfully synthesized with good yields and excellent selectivities in the presence of HF@SiO2 as an environmental friendly acid under solvent-free condition. Mild and green reaction conditions and excellent yields (50-91%) make this method an attractive method for the efficient synthesis of hydroxyaryl ketones. Fries rearrangement of phenyl benzoate in the presence of HF@SiO2 led to p-hydroxybenzophenone, while phenyl acetate in the same conditions produced o-hydroxyacetophenone as a single isomer.

Keywords:

Fries rearrangement, hydroxyaryl ketones, HF@SiO2, solvent-free condition, selective synthesis, isomer.

Affiliation:

Department of Science, Payame Noor University (PNU), PO Box: 19395-4697, Tehran, Department of Science, Payame Noor University (PNU), PO Box: 19395-4697, Tehran, Chemistry and Chemical Engineering Research Center of Iran, PO Box: 14335-186, Tehran

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