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A Novel Synthetic Approach to Diarylmethylpiperazine Drugs

[ Vol. 15 , Issue. 6 ]

Author(s):

Tian Yu, Hongbo Dong*, Zheng Shi*, Lijia Cheng, Xiaoheng Guo, Xinjie Lian and Feng Liu   Pages 485 - 490 ( 6 )

Abstract:


Classical methods for the synthesis of diarylmethylpiperazine drugs generally lead to the generation of high levels of waste. In this study, we have developed a simple and efficient route to the anti-histamine drugs Meclizine 1, Buclizine 2, Clocinizine 3, Cinnarizine 4, Flunarizine 5 and Flotrenizine 6. The advantage of this route lies on the replacement of harmful alkyl halides by readily available alcohols to achieve the N-alkylation of the piperazine unit. This procedure was further extended to the synthesis of other diarylmethylpiperazine drugs and derivatives.

Keywords:

Diarylmethylpiperazine drugs, N-alkylation, synthesis, anti-histamine drugs, derivatives, alcohol.

Affiliation:

College of Medicine, School of Nursing, Chengdu University, Chengdu, Antibiotics Research and Reevaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu, College of Medicine, School of Nursing, Chengdu University, Chengdu, College of Medicine, School of Nursing, Chengdu University, Chengdu, College of Medicine, School of Nursing, Chengdu University, Chengdu, College of Medicine, School of Nursing, Chengdu University, Chengdu, College of Medicine, School of Nursing, Chengdu University, Chengdu

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