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CAN Mediated Mechanochemical Synthesis of Substituted Pyridine Derivatives

[ Vol. 15 , Issue. 8 ]

Author(s):

Radhika Khanna, Aarti Dalal, Kulbir Kadyan, Ramesh Kumar, Parvin Kumar and Ramesh C. Kamboj*   Pages 673 - 677 ( 5 )

Abstract:


A simple, green and cost-effective protocol has been devised for the synthesis of 4-substituted-2,6-dimethyl-3,5-pyridinecarboxylates from Hantzsch-type 1,4-dihydropyridines via rapid oxidation in excellent yields using 1.5 equivalent of ceric ammonium nitrate within 15 minutes in solvent-free conditions. The method was able to furnish the products in excellent yields. The products obtained were characterized by their NMR and melting points data.

Keywords:

CAN, 1, 4-DHP, Hantzsch reaction, catalysis, heterocycles, drugs.

Affiliation:

Department of Chemistry, Kurukshetra University, Kurukshetra-136119, Haryana, Department of Chemistry, Kurukshetra University, Kurukshetra-136119, Haryana, Department of Chemistry, Kurukshetra University, Kurukshetra-136119, Haryana, Department of Chemistry, Kurukshetra University, Kurukshetra-136119, Haryana, Department of Chemistry, Kurukshetra University, Kurukshetra-136119, Haryana, Department of Chemistry, Kurukshetra University, Kurukshetra-136119, Haryana

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