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Synthesis of Secondary Phosphine Oxides by Substitution at Phosphorus by Grignard Reagents

[ Vol. 15 , Issue. 5 ]

Author(s):

Anna Tripolszky and Gyorgy Keglevich*   Pages 387 - 393 ( 7 )

Abstract:


Secondary phosphine oxides (SPOs) are important starting materials in organophosphorus syntheses, and may be the ligands in transition metal complexes. SPOs are obtained from phosphorus trichloride via double substitution by a Grignard reagent followed by hydrolysis, or from dialkyl phosphites by reaction with two equivalents of a Grignard reagent. The preparation of SPOs with two different substituents is of special importance. This minireview gives useful hints for the synthesis of a variety of SPOs that are useful intermediates.

Keywords:

Dialkyl phosphites, grignard reagents, P(III)-chlorides, secondary phosphine oxides, substitution, ligand.

Affiliation:

Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1521 Budapest, Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1521 Budapest

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