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A Direct Access to N-Arylation of Guanidines by Ligand-Free, Copper Catalysis at Room Temperature

[ Vol. 15 , Issue. 8 ]


Manijeh Nematpour*, Elham Abedi and Elahe Abedi   Pages 678 - 681 ( 4 )


The copper (I)-catalyzed cross-coupling reactions between aryl halides and guanidines to produce N-aryl guanidines have been developed. Mild reaction conditions, good yields, ligand-free, easy work-up, no column chromatography, and ease of handling at room temperature are the main aspects of the method.


N-Arylation, ullmann coupling, guanidine, copper-catalyzed, aryl halides, organic.


Young Researchers and Elites Club, Science and Research Branch, Islamic Azad University, Tehran, Pathology Department, Shiraz University of Medical Siences, Shiraz, Department of Hygiene and Quality Control of Food Sciences, Shiraz University of Medical Sciences, Shiraz

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