Submit Manuscript  

Article Details


Direct Hydroxymethylation of C=N Double Bonds

[ Vol. 15 , Issue. 5 ]

Author(s):

Pedro Merino*, Tomas Tejero, Ignacio Delso, Veronica Juste, Manuel Pedron, Sara Orta and Rosa Matute   Pages 375 - 386 ( 12 )

Abstract:


Direct hydroxymethylation of C=N double bonds including imines, nitrones, oximes, hydrazones and iminium salts is a less explored synthetic approach to 1,2-amino alcohols that provides good alternatives to the classical methods. The review deals with nucleophilic additions of organometallic hydroxymethyl reagents and lithiated alkoxyallenes to C=N double bonds. Reductive cross couplings between C=N double bonds and aldehydes or ketones are also discussed.

Keywords:

Hydroxymethylation, 1, 2-amino alcohols, imines, nitrones, hydrazones, iminium, reductive cross-couplings.

Affiliation:

Instituto de Biocomputacion y Fisica de Sistemas Complejos (BIFI), Universidad de Zaragoza, 50009 Zaragoza, Instituto de Sintesis Quimica y Catalisis Homogenea (ISQCH), Universidad de Zaragoza-CSIC, 50009 Zaragoza, Servicio de Resonancia Magnetica Nuclear, CEQMA, Universidad de Zaragoza-CSIC, 50009 Zaragoza, Instituto de Sintesis Quimica y Catalisis Homogenea (ISQCH), Universidad de Zaragoza-CSIC, 50009 Zaragoza, Instituto de Biocomputacion y Fisica de Sistemas Complejos (BIFI), Universidad de Zaragoza, 50009 Zaragoza, Instituto de Sintesis Quimica y Catalisis Homogenea (ISQCH), Universidad de Zaragoza-CSIC, 50009 Zaragoza, Escuela Universitaria de Ingenieria Industrial, Edificio Torres Quevedo, Campus Actur, 50018 Zaragoza

Graphical Abstract:



Read Full-Text article