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Rapid and Efficient Synthesis, Characterization and Antimicrobial Activity of Some Methylanthranilate Derived Odorant Schiff Bases

[ Vol. 15 , Issue. 7 ]

Author(s):

Prasoon Kumar Kaushik, V.K. Varshney*, Pallavi Bhatia, Pawan Kumar and S.V. Shukla   Pages 620 - 626 ( 7 )

Abstract:


Synthesis of seven odorant Schiff bases of methylanthranilate, an aroma constituent of blossom essential oils, with naturally occurring carbonyl compounds (citral, citronellal, cuminaldehyde, vanillin, veratraldehyde, acetophenone and α-ionone) employing conventional and microwave irradiation methods was carried out. Elemental and spectral (FT-IR, 1H NMR and 13C NMR) analysis of these compounds supported their structures. These Schiff bases had olfactory attributes suitable for various fragrance compositions. Microwave irradiation method was efficient in terms of reduced reaction time, solvent use, and increased yields of these compounds without affecting their olfactory characteristics. These compounds also displayed varied antimicrobial activity against Aspergillus niger, Penicillium chrysogenum, Staphylococcus aureus and Escherichia coli.

Keywords:

Antimicrobial activity, carbonyl compounds, methylanthranilate, microwave irradiation, olfactory property, Schiff base.

Affiliation:

Chemistry Division, Forest Research Institute, P.O. New Forest, Dehradun 248 006, Chemistry Division, Forest Research Institute, P.O. New Forest, Dehradun 248 006, Forest Pathology Division, Forest Research Institute, P.O. New Forest, Dehradun 248 006, Department of Electrical and Computer Engineering, University of Alberta, 9211-116 St, Edmonton, Alberta, Fragrance & Flavor Development Center, Makrandnagar, Kannauj

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