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A One-Pot Multicomponent Synthesis of Naphthoxazin-3-one Derivatives Using Amberlite IRA-400 Cl Resin as Green Catalyst

[ Vol. 15 , Issue. 7 ]

Author(s):

Gurusamy Harichandran*, Parkunan Parameswari and Ponnusamy Shanmugam   Pages 600 - 605 ( 6 )

Abstract:


An efficient Amberlite IRA-400 Cl resin catalyzed, solvent-free, one-pot synthesis of 1- aryl-1,2-dihydro-3H-naphtho[1,2-e][1,3]oxazin-3-ones via three-component reaction of arylaldehydes, urea, and β-naphthol are described. This method offers advantages such as easy work-up, low environmental impact, shortened reaction times, and high yields. The catalyst recovered was reused four times without significant loss of catalytic activity.

Keywords:

Amberlite IRA-400 Cl resin, naphthoxazin-3-ones, solvent-free conditions, three-component reaction, green catalyst, therapeutic agents.

Affiliation:

Department of Polymer Science, University of Madras, Guindy Campus, Chennai 600 025, Department of Polymer Science, University of Madras, Guindy Campus, Chennai 600 025, Organic Chemistry Division, CSIR-Central Leather Research Institute (CLRI), Adyar, Chennai 600 020

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