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A Novel Approach for Substitution of Sulfonate Group by (1H)-imidazole moiety: An Application for Synthesis of Novel Benzyl Imidazolylcarbamates

[ Vol. 15 , Issue. 7 ]

Author(s):

Vijaya Durga Thripuram, Hari Babu Bollikolla*, Sivanagi Siva Nagi Reddy Mule, Sailaja Kumari Battula and Vasu Babu Ala   Pages 569 - 574 ( 6 )

Abstract:


An efficient and convenient substitution protocol was developed for the synthesis of novel benzyl (1-methyl-1H-imidazol-5-yl) (aryl) methyl carbamate derivatives from α-amido sulphones with a solution 5-bromo-1-methyl-(1H)-imidazole in THF under Hexamethylphosphoramide (HMPA) and t-BuLi medium at -78oC to room temperature. The reactions were monitored with TLC for about 3-4 h. The yields obtained were also considerably good.

Keywords:

α-amido sulphones, benzyl (imidazolyl) (aryl) methyl carbamate, Hexamethylphosphoramide, t-BuLi, imidazole, imidazolyl carbamate.

Affiliation:

Department of Chemistry, University College of Sciences, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur - 522510, A.P, Department of Chemistry, University College of Sciences, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur - 522510, A.P, Department of Chemistry, University College of Sciences, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur - 522510, A.P, Department of Chemistry, University College of Sciences, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur - 522510, A.P, Department of Chemistry, University College of Sciences, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur - 522510, A.P

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