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Bio-based Material as Medium, Mild and Reusable Catalyst for Paal– Knorr Pyrrole Synthesis with and Without Ultrasonic Irradiation

[ Vol. 15 , Issue. 3 ]

Author(s):

Abha Sharma*, Illa Siva Kalyani and Anam Fatima   Pages 226 - 232 ( 7 )

Abstract:


Background: Pyrrole moiety is found in naturally occurring compounds such as chlorophyll, haem, and vitamin B12 and present in a number of drugs for example atorvastatin, ketorolac, elopiprazole, tolmetin and sunitinib. Various methods have been used for the synthesis of pyrrole derivatives; however, still there is a need for environmentally benign and economic protocol.

Method: We have reported a simple, mild and speedy synthesis of N-substituted 2,5-dimethyl pyrrole derivatives in ‘’GAAS’’ as medium and catalyst at room temperature and under ultrasound irradiation.

Results: This protocol was employed for the synthesis of various 2,5-dimethyl-N-substituted pyrrolederivatives using both aliphatic as well as aromatic amines in short time (2 to 10 minutes)with excellent yield (84-95%) at room temperature and under ultrasonic irradiation. The catalytic system “GAAS’’ was regenerated and reused five times effectively without major loss of activity.

Conclusion: In conclusion, we have developed an eco-friendly, simple, faster, reusable, mild, and efficient protocol for the synthesis of N-substituted pyrrole derivatives. This bio-based protocol is cost-effective and greener methodology for the synthesis of biologically active N-substituted pyrrole derivatives.

Keywords:

GAAS, ultrasound, N-substituted pyrrole derivatives, catalyst, organic synthesis, irradiation.

Affiliation:

Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Raebareli, Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Raebareli, Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Raebareli

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