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Expeditious and Green Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones Catalyzed by Nano-MgO

[ Vol. 15 , Issue. 6 ]

Author(s):

Hamzeh Kiyani*, Mohsen Tazari and Fatemeh Ghorbani   Pages 523 - 529 ( 7 )

Abstract:


An efficient synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives using nanocrystalline magnesium oxide (nano-MgO) as a catalyst from 2-aminobenzamide and various aldehydes/ketones under aqueous conditions at room temperature is described. Nano-MgO was synthesized by the precipitation and hydrothermal treatment of aqueous salt solution as reported previously. The structure of nano-MgO was characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM) analysis. Simple conditions, environmentally benign, good to excellent yields and comparatively shorter reaction times are the advantages of this protocol.

Keywords:

2-Aminobenzamide, aldehyde, 2, 3-dihydroquinazolin-4(1H)-one, green, nano-MgO, water.

Affiliation:

School of Chemistry, Damghan University, 36715-41167 Damghan, School of Chemistry, Damghan University, 36715-41167 Damghan, School of Chemistry, Damghan University, 36715-41167 Damghan

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