A Concise Stereoselective Total Synthesis of (–) - Cephalosporolide D

Author(s):

Yapuri Umanadh, Gudaparthi Omprakash and Narahari Srinivasareddy   Pages 424 - 428 ( 5 )

Abstract:

A concise stereoselective total synthesis of (-) - Cephalosporolide D, an eight membered lactone ring has been derived from low cost and easily available starting material (±)-propylene epoxide. The key steps involved in this concise synthesis are Sharpless kinetic resolution, Grignard reaction and Yamaguchi macrolactonisation.

Keywords:

(±)-propylene epoxide, sharpless kinetic resolution, yamaguchi macrolactonisation, stereoselective synthesis and (-) - cephalosporolide D.

Affiliation:

R&D Division, Cadila Pharmaceuticals Limited, Dholka, Ahmedabad-387 810, Gujarat, India.

Graphical Abstract:

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