Yapuri Umanadh, Gudaparthi Omprakash and Narahari Srinivasareddy Pages 424 - 428 ( 5 )
A concise stereoselective total synthesis of (-) - Cephalosporolide D, an eight membered lactone ring has been derived from low cost and easily available starting material (±)-propylene epoxide. The key steps involved in this concise synthesis are Sharpless kinetic resolution, Grignard reaction and Yamaguchi macrolactonisation.
(±)-propylene epoxide, sharpless kinetic resolution, yamaguchi macrolactonisation, stereoselective synthesis and (-) - cephalosporolide D.
R&D Division, Cadila Pharmaceuticals Limited, Dholka, Ahmedabad-387 810, Gujarat, India.