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Sodium Benzenesulfinates: Novel and Effective Organo Catalyst for Three Component Synthesis 5,6,7,8-Tetrahydro-4H-chromene Derivatives Under Ultrasound Irradiation

[ Vol. 12 , Issue. 4 ]


Mehdi Abaszadeh and Mohammad Seifi   Pages 271 - 276 ( 6 )


Sodium benzenesulfinates, as a new organo catalyst, can be used to synthesize tetrahydro- 4H-chromene derivatives by three component reaction of cyclic β-dicarbonyl compounds, malononitrile, and aromatic aldehydes, in H2O/EtOH, under ultrasound irradiation at room temperature. Inexpensiveness, stability and the potential of being easily obtained can be noted as preponderance of these catalysts. Furthermore, high conversions, short reaction times and cleaner reaction profiles are some of the advantages of this method. Moreover, H2O/EtOH (7:3) was selected as a green solvent.


Sodium benzenesulfinates, tetrahydro-4H-chromene derivatives, three component reactions, ultrasound irradiation, cyclic β-dicarbonyl compounds, aromatic aldehydes.


Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman 76175493, Iran.

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