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Synthesis and Biological Activity of Some New N1-(6-fluoro-4-oxoquinolin- 8-yl)amidrazones

[ Vol. 11 , Issue. 9 ]

Author(s):

Mohammed M. Abadleh, Mustafa M. El-Abadelah, Salim S. Sabri, Qasem M.A. Abdallah, Abdelrahman Nasr and Mohamed F. El-Badawy   Pages 664 - 670 ( 7 )

Abstract:


A selected set of new N 1- (6-fluoro-4-oxoquinolin-8-yl)amidrazone-3-carboxylates (8a_e) incorporating Npiperazines and related congeners has been synthesized by reacting the hydrazonoyl chloride, derived from 8-amino-6- fluoro-4-oxoquinloine-3-carboxylate, with the appropriate sec-cyclic amine. Their suggested structures are supported by elemental analysis, 1H NMR, 13C NMR and ESI-HRMS spectral data. These novel compounds (8a_e) were screened for their antitumor and antibacterial activity. While no significant antitumor activity was observed, compounds 8a, 8b and 8d have shown moderate in vitro antibacterial activity against Gram positive bacteria cells. Unlike the others, compound 8a has also shown to moderately inhibit the growth of Gram negative bacteria.

Keywords:

N1-(4-Oxoquinolin-8-yl)hydrazonoyl chloride, nitrile imines, 1, 3-nucleophilic addition, amidrazones, antibacterial activity.

Affiliation:

Chemistry Department, Faculty of Science, The University of Jordan, Amman 11942, Jordan.

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