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Facile Synthesis of Novel N4-Substituted 2-(Trifluoromethyl)-tetrahydrobenzothieno[ 2,3-d]pyrimidine Derivatives

[ Vol. 11 , Issue. 9 ]


Fasong Wang, Hui Gao, Ping Yang, Yan Wang and Xinjian Song   Pages 700 - 705 ( 6 )


A series of novel N4-substituted 2-(trifluoromethyl)-tetrahydrobenzothieno[2,3-d]pyrimidine derivatives were synthesized by a facile three-step procedure that presented such advantages as easily accessible starting materials, mild reaction conditions, simple protocol and good overall yields. The structures of the title compounds were confirmed by IR, 1H NMR, 13C NMR, EI-MS, elemental analysis, and single-crystal X-ray diffraction.


Facile synthesis, crystal structure, Gewald reaction, thieno[2, 3-d]pyrimidines, fluorinated compounds.


Key Laboratory of Biologic Resources Protection and Utilization of Hubei Province, Hubei Minzu University, Xueyuan Road, Enshi, Hubei 445000, P.R. China.

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