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Synthesis of 4-oxo-2,5-cyclopentadiene Using Multi-component Reactions of Primary Amines and Electron Deficient Acetylenic Compounds with Triphenylphosphine in Water

[ Vol. 11 , Issue. 6 ]

Author(s):

Samereh Seyfi, Faramarz Rostami-Charati, Zinatossadat Hossaini and Mohammad R. Zardoost   Pages 409 - 412 ( 4 )

Abstract:


A water-accelerated multicomponent synthesis of organic target molecules has been used as a key method for the preparation of cyclopentadiene derivatives. The three-component condensation reactions of primary amines with alkyl propiolates in the presence of triphenylphosphine in water at 80 °C are developed as efficient and clean green synthetic procedures for the high-yielding preparation of 4-oxo-2,5-cyclopentadiene-1,2-dicarboxylate derivatives.

Keywords:

Cyclopentadiene, primary amines, triphenylphosphine, alkyl propiolates, multi-component reaction.

Affiliation:

Department of Chemistry, Faculty of Science, Gonbad Kavous University, P.O. Box 163, Gonbad, Iran.

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