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TBAOH Mediated: An Efficient and Simple Procedure for Alkylation of Alcohols, Phenols and Thiols Under Neat Aqueous Conditions

[ Vol. 11 , Issue. 5 ]


Mohammad Soleiman-Beigi, Mosstafa Kazemi, Reza Aryan and Lotfi Shiri   Pages 321 - 326 ( 6 )


Aqueous tetra-n-butyl ammonium hydroxide solution (TBAOH) has been used as a green reaction medium and efficient catalyst for the O-alkylation of alcohols and phenols as well as S-alkylation of thiols under a novel, mild and convenient procedure. Herein, TBAOH has been used as a strong base, medium of reaction and phase transfer reagent.


Tetra-n-butyl ammonium hydroxide, ethers, thioethers, neat condition, alkylation.


Department of Chemistry, Faculty of Basic Sciences, Ilam University, P.O. Box 69315-516, Ilam, Iran.

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