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Copper and Iron-assisted Palladium-catalyzed Direct Arylation of Azoles with Arylboronic Acids under Ligand and Base-free Conditions

[ Vol. 10 , Issue. 9 ]

Author(s):

Xiang-Mei Wu and Qiu-Xian Shen   Pages 668 - 673 ( 6 )

Abstract:


The direct arylation of azoles with arylboronic acids is effectively promoted by PdCl2 in the presence of copper and iron salts under ligand and base-free conditions. This reaction can be applied to heterocycles such as benzothiazole, benzoxazole, 1-methylbenzimidazole and 4,5-dimethylthiazole with moderate to good yields.

Keywords:

Palladium, copper, iron, arylation, arylboronic acid.

Affiliation:

Department of Chemistry, College of Science, Lishui University, Lishui, Zhejiang 323000, China.



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