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Microwave-Assisted Solid-Liquid Phase Alkylation of Naphthols

[ Vol. 10 , Issue. 5 ]

Author(s):

Erika Balint, Orsolya Kovacs, Laszlo Drahos and Gyorgy Keglevich   Pages 330 - 336 ( 7 )

Abstract:


The microwave promoted alkylation of 1- and 2-naphthols with benzyl, butyl, ethyl and isopropyl halides in the presence of an alkali carbonate may result in O- and C-alkylated products. The alkylations were O-selective in the presence of K2CO3 in acetonitrile as the solvent and in the absence of phase transfer catalyst. The alkylations utilizing butyl and ethyl halides were also O-selective in solventless accomplishment and in the presence of triethylbenzylammonium chloride.

Keywords:

O-alkylation, C-alkylation, microwave, phase transfer catalyst.

Affiliation:

Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1521 Budapest, Hungary.



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