Digambar Balaji Shinde, Boddu Shashi Kanth, Avula Satyakumar, V.T. Kamble and Biswanath Das Pages 317 - 323 ( 7 )
The stereoselective synthesis of the unsaturated lactone intermediates, (S) - and (R)-2-(6-oxo-3, 6-dihydro-2Hpyran- 2-yl) acetaldehydes has been accomplished from propane 1,3 diol employing Maruoka asymmetric allylation and ring closing metathesis reaction. The intermediates were converted into two natural dihydropyranones, 6 (R)-4-oxopent-2- enyl 5,6-dihydro-2H-pyran-2-one and (R)- rugulactone and their enantiomers through Wittig olefination.
Lactone intermediates, Wittig olefination, maruoka asymmetric allylation, 6 -(R)-4-oxopent-2-enyl 5, 6-dihydro- 2H-pyran-2-one, (R)- rugulactone, enantiomer.
Natural Product Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad- 500007, India.