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A Mild and Green Method for the N-BOC Protection of Amines without Assistant of Catalyst Under Solvent-free Conditions

[ Vol. 10 , Issue. 2 ]


Mohammad Majid Mojtahedi, Nina Niknejad and Hojat Veisi   Pages 121 - 125 ( 5 )


A facile, green and versatile method for the Boc protection of amines has been developed by a treatment with (Boc)2O without any additive at room temperature. The method is general for the preparation of N-Boc derivatives of aliphatic (acyclic and cyclic), aromatic, and heteroaromatic amines; primary and secondary amines. The advantages of this method are green, simplicity, short reaction times and excellent yields.


N-BOC protection, green, catalyst-free, solvent-free


Department of Chemistry, Payame Noor University (PNU), 19395-4697 Tehran, Iran.

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