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An Efficient Green MCR Protocol for the Synthesis of New Betti Bases via Mannich-Type Reaction

[ Vol. 9 , Issue. 6 ]


Abolfazl Olyaei, Mojgan Zarnegar, Mahdieh Sadeghpour and Mortaza Rezaei   Pages 451 - 456 ( 6 )


An efficient solvent and catalyst-free synthesis of new Betti base derivatives via Mannich-type one-pot threecomponent condensation reaction of aminodiazines, salicylaldehyde and naphthols under solvent-free conditions is described. The reactions occur at 80 oC giving high to excellent yields of the products. The work-up procedure is very simple and the products do not require further purification with column chromatography.


Aminodiazine, Betti base, naphthol, salicylaldehyde, solvent-free, three- component, 2-aminopyrimidine, temperature, aminonaphthols


Department of Chemistry, Payame Noor University, PO BOX 19395-3697, Tehran, Iran.

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